News Bulletin
The baby was brought to Fortis Escorts Heart Institute, Okhla, in a serious condition with breathing difficulties, sepsis-like symptoms, heart failure signs, elevated heart rate, excessive perspiration, inability to feed, liver enlargement, and failure to gain weight. An echocardiogram revealed that the baby suffered from a hole in the heart, also known as patent ductus arteriosus (PDA) — a condition where an extra blood vessel is found in babies before birth and just after birth.
Amidst concerns over the outbreak of deadly virus infections like Nipah in Kerala, the state on Monday reported a rare case of recovery from amoebic meningoencephalitis, which has a 97 percent mortality rate. State Health Minister Veena George's office on Monday confirmed that it was a rare occurrence, which has a mortality rate of 97 percent and it is believed that only 11 persons in the world so far recovered from the infection. Earlier detection of the infection helped in speedy recovery of the boy. The minister also praise the efforts of the medical team that treated the boy.
For the first time, scientists have grown 3D brain models using cells from multiple people. The new hybrid creations, which researchers have dubbed "chimeroids," are a variation of brain organoids — tiny 3D models made of tissue that mimic the structure and function of a full-size brain. These models are more accurate to human biology than 2D cellular models or animals like lab mice. Because of this, scientists hope that the models will accelerate drug research and development.
Ten years ago, a scan showed that I had torn the meniscus in my knee. The pain was bad and I was limping a lot of the time. My doctor recommended arthroscopic knee surgery to fix it. Being scared of scalpels, I asked whether there were other options. He said I could try physiotherapy, but that it was unlikely to work. I tried the physio and did the recommended exercises diligently, and my knee pain and function returned to almost normal. I even ran my first (and only) marathon a year later.
A small farmer from a remote village walks into the nearest town’s health clinic. He breathes into a tube connected to a Vionix analyser. This device compares the farmer’s breath with hundreds of millions of other samples from around the world. An AI model, running on the cloud, identifies patterns of disease manifestations in the spectral signatures of the breath sample and instantly provides results on the farmer’s smartphone.
The first man to receive a genetically modified pig kidney transplant has died two months after the operation, the hospital which carried out the procedure has said. Richard "Rick" Slayman, 62, was suffering with end-stage kidney disease before undergoing the operation in March. Massachusetts General Hospital (MGH) said on Sunday there was no indication his death was a result of the transplant.
A girl born deaf can now hear unaided after participating in a world-first trial. The CHORD study is for children born with hearing loss due to a genetic condition called auditory neuropathy. Auditory neuropathy is a condition where the ear can detect sound normally, but has a problem sending signals to the brain.
A study found that one-third of patients receiving surgery for adult spinal deformity (ASD) also have severe hip osteoarthritis (OA), which can lead to poor spinal alignment and physical functionality. Findings of the study published in The Journal of Bone & Joint Surgery.
For the roughly 1.5 million Americans per year who survive a traumatic brain injury, health outcomes vary widely. Not only can these injuries lead to a loss of coordination, depression, impulsivity, and difficulty concentrating, but they come with an amplified risk for developing dementia in the future. The glaring absence of treatments for such a widespread condition drove a team of scientists at Gladstone Institutes to uncover, on a molecular level, how traumatic brain injuries trigger neurodegeneration—and just as importantly, how to target that process to prevent long-term damage.
Sapience Therapeutics announced that the first patient has been enrolled in its phase 2 dose expansion study evaluating ST316, the company’s first-in-class antagonist of ß-catenin. Enrollment of the study’s phase 1 monotherapy dose escalation portion was completed in July 2024.
Researchers have identified nearly 200 chemicals linked to breast cancer in food packaging materials and plastic tableware, with many capable of migrating into the human body. In a study published in ‘Frontiers in Toxicology’, they highlighted the presence of at least 189 potential breast carcinogens, including PFAS, bisphenols, and phthalates, in food contact materials (FCMs). Jane Muncke, study co-author, managing director and chief scientific officer at the Food Packaging Forum, a non-profit foundation based in Zurich, Switzerland said, “There is strong evidence that 76 known or potential breast carcinogens from food contact materials recently purchased all over the world can be found in people.”
British drugmaker GSK said on Wednesday its experimental herpes simplex virus (HSV) vaccine candidate failed to meet the main goal of a mid-stage trial and would not be taken forward to a late-stage trial.
A pooled analysis from the BOREAS and NOTUS phase 3 studies showed that Dupixent reduced exacerbations and improved lung function compared to placebo in adults with uncontrolled chronic obstructive pulmonary disease (COPD) and evidence of type 2 inflammation (i.e., raised blood eosinophils).
Positive results from the HERCULES phase 3 study showed that tolebrutinib, Sanofi’s oral brain-penetrant BTK inhibitor, met the primary endpoint of improvement over placebo in delaying time to onset of confirmed disability progression (CDP) in people with non-relapsing secondary progressive MS (nrSPMS).
This WHO Medical Product Alert refers to one batch of falsified Oxymorphone Hydrochloride 40mg. The falsified product was detected in the unregulated supply chain in Finland and reported to WHO in July 2024 by the Finnish Medicines Agency (FIMEA). Oxymorphone Hydrochloride is a semi-synthetic opioid used to treat moderate to severe pain. However, laboratory analysis of samples of the falsified product found that the tablets contained metonitazene instead.
Merck announced positive topline results from its phase 2b/3 clinical trial (MK-1654-004) evaluating clesrovimab (MK-1654), the company’s investigational prophylactic monoclonal antibody designed to protect infants from respiratory syncytial virus (RSV) disease.
The UK will become the first country in the world to have a national programme that uses the same vaccine to protect both newborns and older adults against respiratory syncytial virus (RSV).
Roche announced that it has received the CE Mark for its Accu-Chek SmartGuide continuous glucose monitoring (CGM) solution.
Cancer patients should not delay or stop their treatment by following unproven remedies, oncologists at Tata Memorial Hospital said after former India cricketer Navjot Singh Sidhu claimed at a presser that his wife Navjot Kaur defeated stage 4 cancer with dietary and lifestyle changes. In a statement posted on X, the Director of Tata Memorial Hospital, Dr C S Pramesh, said, "Parts of the video imply that starving the cancer by not eating dairy products and sugar, consuming haldi (turmeric) and neem helped cure her 'incurable' cancer." These comments have no high quality evidence to support them, the statement signed by 262 oncologists from the Tata Memorial Hospital, both past and present, said.
Delhi AIIMS has launched the GRASSROOT (Gravity Stent-Retriever System for Reperfusion of Large Vessel Occlusion Stroke Trial) clinical trial to evaluate the safety and efficacy of an advanced brain stent for treatment of stroke clots particularly in Indian population. The study went live for enrolment on August 15 and the first patient was successfully treated on August 25. Subsequently, the patient was discharged from hospital, said Dr Shailesh Gaikwad, Professor and Head of Department of Neuroimaging and Intervential Neuroradiology at Neurosciences Centre, All India Institute of Medical Sciences (AIIMS), Delhi. The GRASSROOT trial is the first-ever study in India to test a novel next generation brain stent designed for Indian and Asian healthcare scenarios.
Yashoda Medicity, a new healthcare facility by Yashoda Foundations in Indirapuram, has introduced three advanced technologies in its Radiation Oncology department, positioning itself as a leader in cancer treatment and care in the region. The adoption of these technologies makes Yashoda Medicity the only hospital in Southeast Asia equipped with such equipment.
Wockhardt Hospitals, Mira Road, organised the third season of its Cyclothon on September 1st, attracting more than 1,200 cyclists from across Mumbai, including major cycling groups. The event was held to raise awareness about heart health ahead of World Heart Day, which falls on September 29, 2024. Participants cycled through a 30 km and 15 km route across Uttan-Gorai Island, promoting fitness and heart health.
A growing number of Bengalureans, especially younger individuals, are reporting persistent joint pain long after recovering from dengue, causing concern among medical experts. Although they test negative for the virus, these patients experience severe joint discomfort, a symptom that was absent during their illness. Doctors are now investigating whether a mutation in the dengue virus may be responsible for this unexpected development, raising concerns about its impact on the city's youth.
In a country where vaccination is often associated only with childhood immunisation and the need for adult vaccines is often overlooked, HCMCT Manipal Hospital and Pfizer India have collaborated to launch a dedicated Centre for adult vaccination at HCMCT Manipal Hospital, Dwarka, New Delhi, strengthening the delivery of adult vaccines.
A urine dipstick test, a simple and cost-effective diagnostic tool, can significantly prevent complications such as organ failure, heart attacks, and premature deaths, particularly among those with hypertension and diabetes, according to a newly released report by the Tamil Nadu Public Health Department. Doctors analyzed data from 5.7 million people across Tamil Nadu who took the test between July 2023 and May 2024 as part of a state ‘urine dipstick testing program’ for the early detection of chronic kidney disease (CKD). The test was administered at all primary health centers and health sub-centers for individuals with diabetes and hypertension. The urine dipstick test, recommended during routine check-ups or when urinary tract infection, kidney disease, or diabetes is suspected, involves dipping a plastic stick with chemically treated pads into a urine sample. The results revealed that 13,082 patients had high levels of albumin, an important indicator of kidney damage.
Although dengue is known to cause mild flu-like symptoms, the mosquito-borne viral illness has profound neurological implications that are often overlooked, said experts on Tuesday. Amid the monsoon in India, dengue cases have spiralled in various parts of the country, including Karnataka, Kerala, Telangana, Andhra Pradesh, Odisha, Delhi and Maharashtra. According to the latest data from the Municipal Corporation of Delhi (MCD), there have been 246 dengue cases in the national capital till June 30 this year. During the same period in 2023, Delhi saw only 122 cases, 143 cases in 2022, 36 cases in 2021, and 20 cases in 2020.
From polio to the coronavirus, vaccines play a pivotal role in protecting human health against a range of perilous diseases. As researchers strive to comprehend viruses and innovate new vaccines, it’s imperative to emphasise the significance of immunisation. Hence, World Immunisation Week is observed annually from April 24 to 30. During this week, let’s explore the significance of both traditional and emerging vaccines that are essential for everyone.
A new RSV drug designed to protect young children was 93 percent effective at preventing hospitalization for the viral disease, a new study reports. Furthermore, the drug was 89 percent effective at preventing all types of doctor visits for RSV, which is short for "respiratory syncytial virus."
Kumamoto University scientists have unveiled a novel compound, HPH-15, with dual effects of reducing blood glucose levels and combating fat accumulation, marking a significant leap in diabetes treatment innovation. Type 2 diabetes, a condition affecting millions worldwide, is often accompanied by complications like fatty liver and insulin resistance, which challenge current treatment methods.
Effective immunity hinges on the ability to sense infection and cellular transformation. In humans, there is a specialized molecule on the surface of cells termed MR1. MR1 allows sensing of certain small molecule metabolites derived from cellular and microbial sources; however, the breadth of metabolite sensing is unclear.
Already the go-to drug of choice for millions with type 2 diabetes, metformin might also fight lung cancer if those patients have it as well, new research shows. Metformin appears to help boost the benefits of immunotherapy drugs used to fight lung tumors, according to a team led by Dr. Sai Yendamuri. He directs thoracic surgery at Roswell Park Comprehensive Cancer Center in Buffalo, N.Y.
The biggest and most comprehensive analysis of glucagon-like peptide-1 (GLP-1) receptor agonists on kidney and cardiovascular outcomes shows they have significant benefits in people with and without diabetes.1 Findings were published today in The Lancet Diabetes & Endocrinology. Originally developed to treat diabetes, GLP-1 receptor agonists mimic the action of a hormone called glucagon-like peptide 1, which stimulates insulin production and lowers blood sugar levels. More recently, they have emerged as effective treatments for obesity - slowing digestion, increasing feelings of fullness, and reducing hunger.
A new study has shown that variation in the microbiota of the human gut impacts the pharmacokinetics of tamoxifen and thus the effectiveness of the drug. The finding, published in the journal mBio of the American Society for Microbiology, suggests that in the future, doctors may use a simple test on a patient's stool to check for certain bacteria in the gut that might help predict whether tamoxifen will work for them.
Weight-loss and diabetes drug tirzepatide can reduce the risk of death or worsening heart failure for patients with heart failure, preserved heart pump function and obesity, new research from UVA Health reveals. The drug, from pharmaceutical company Eli Lilly and Co., was tested in the SUMMIT clinical trial at 146 sites in the United States and abroad. A total of 731 patients with diastolic heart failure and a body mass index (BMI) of 30 or above were randomized to receive injections of either tirzepatide or a harmless placebo. The researchers then followed the patients for a median period of two years.
A multitude of genes have been linked to the development of Alzheimer's disease. Specifically how those genes might influence the progression of neurodegeneration remains something of a black box though, in part because of the challenges of examining in molecular detail the brain of a living patient. Using cerebrospinal fluid (CSF) collected from living patients, a team of researchers at Washington University School of Medicine in St. Louis has for the first time linked disease-related proteins and genes to identify specific cellular pathways responsible for Alzheimer's genesis and progression. Because these proteins were gathered from CSF, they are a good proxy for activity in the brain, and several of them may be potential targets for therapies.
A collaboration of researchers led by Emory University Rollins School of Public Health, Atlanta, is urging caution when prescribing off-label glucose-lowering drugs to individuals with type 1 diabetes (T1D). Both glucagon-like peptide-1 receptor agonists (GLP-1RA) and sodium-glucose cotransporter 2 (SGLT2) inhibitors have shown significant benefits for cardiovascular and renal health in other populations, particularly in patients with type 2 diabetes. GLP-1RAs are also known for their weight loss effects.
Biological E Limited's Corbevax is being administered to children in the age group 12-14 in India. This age group got the Indian government's nod to be receive vaccine against the novel coronavirus from 16 March, Wednesday. These children have to register for getting the vaccine on the CoWIN portal. India's third indigenous anti-Covid vaccine has been manufactured by Hyderabad-based Biological E Limited. Biological E has supplied 5 crore doses of Corbevax to the Centre, which has then distributed the same to states.
Biological E seems confident regarding getting emergency use authorisation for use of its COVID vaccine Corbevax among children in the age group of 5-12 years. Currently, the vaccine is inoculated among children in the age group of 12 to 14 years The Hyderabad-based company Is qualified to produce around 1 billion dosages of Corbevax annually and it is geared up to meet any increase in demand. Currently, the company has produced 30 crore vaccines as part of its commitment made to the Government of India, with 5 crore dosages already supplied.
Biotech firm Biological E. Limited is geared to facilitate the first phase of the vaccination drive for the 12-15 age group and is ready with 30 crore doses of which five crore has been rolled out to 17 different sites in the country, said a top official of the firm. "This is the most affordable COVID-19 vaccine for the Government of India which is providing free vaccination to all eligible citizens. The pricing of CORBEVAX in the private market will be Rs 800 (and inclusive of all taxes and vaccine administration charges will cost Rs 990) The vaccine is being sold at Rs 145 per dose to the government," Mahima Datla, managing director of Biological E. Limited said at a virtual media interaction on Wednesday. "We have an annual production capacity upto one billion vaccines," Datla said. The firm collaborated with the Texas Children's Hospital and the Baylor College to develop Corbevax vaccine. Dynavax, Inc from USA supported Corbevax development by providing the adjuvant and THSTI Delhi conducted key immunogenicity testing as part of a comprehensive clinical trial development plan.
Only about 3,800 children aged between 12 and 14 were vaccinated against Covid-19 in the city on Wednesday, the first day of vaccination for this cohort in the country. All the children were administered Corbevax, India's first indigenously developed protein subunit vaccine against Covid-19, made by Biological E. Each dose in the private market will cost Rs 800 per dose, excluding GST, and around Rs 990, including taxes and administration charges. For the government, the price will be Rs 145. There are nearly 6.2 lakh children in this age group in Delhi who are eligible for the vaccine. Hospital officials said the first day saw a lukewarm response; footfall is expected to pick up after Holi.
The baby was brought to Fortis Escorts Heart Institute, Okhla, in a serious condition with breathing difficulties, sepsis-like symptoms, heart failure signs, elevated heart rate, excessive perspiration, inability to feed, liver enlargement, and failure to gain weight. An echocardiogram revealed that the baby suffered from a hole in the heart, also known as patent ductus arteriosus (PDA) — a condition where an extra blood vessel is found in babies before birth and just after birth.
Amidst concerns over the outbreak of deadly virus infections like Nipah in Kerala, the state on Monday reported a rare case of recovery from amoebic meningoencephalitis, which has a 97 percent mortality rate. State Health Minister Veena George's office on Monday confirmed that it was a rare occurrence, which has a mortality rate of 97 percent and it is believed that only 11 persons in the world so far recovered from the infection. Earlier detection of the infection helped in speedy recovery of the boy. The minister also praise the efforts of the medical team that treated the boy.
For the first time, scientists have grown 3D brain models using cells from multiple people. The new hybrid creations, which researchers have dubbed "chimeroids," are a variation of brain organoids — tiny 3D models made of tissue that mimic the structure and function of a full-size brain. These models are more accurate to human biology than 2D cellular models or animals like lab mice. Because of this, scientists hope that the models will accelerate drug research and development.
Ten years ago, a scan showed that I had torn the meniscus in my knee. The pain was bad and I was limping a lot of the time. My doctor recommended arthroscopic knee surgery to fix it. Being scared of scalpels, I asked whether there were other options. He said I could try physiotherapy, but that it was unlikely to work. I tried the physio and did the recommended exercises diligently, and my knee pain and function returned to almost normal. I even ran my first (and only) marathon a year later.
A small farmer from a remote village walks into the nearest town’s health clinic. He breathes into a tube connected to a Vionix analyser. This device compares the farmer’s breath with hundreds of millions of other samples from around the world. An AI model, running on the cloud, identifies patterns of disease manifestations in the spectral signatures of the breath sample and instantly provides results on the farmer’s smartphone.
The first man to receive a genetically modified pig kidney transplant has died two months after the operation, the hospital which carried out the procedure has said. Richard "Rick" Slayman, 62, was suffering with end-stage kidney disease before undergoing the operation in March. Massachusetts General Hospital (MGH) said on Sunday there was no indication his death was a result of the transplant.
A girl born deaf can now hear unaided after participating in a world-first trial. The CHORD study is for children born with hearing loss due to a genetic condition called auditory neuropathy. Auditory neuropathy is a condition where the ear can detect sound normally, but has a problem sending signals to the brain.
A study found that one-third of patients receiving surgery for adult spinal deformity (ASD) also have severe hip osteoarthritis (OA), which can lead to poor spinal alignment and physical functionality. Findings of the study published in The Journal of Bone & Joint Surgery.
For the roughly 1.5 million Americans per year who survive a traumatic brain injury, health outcomes vary widely. Not only can these injuries lead to a loss of coordination, depression, impulsivity, and difficulty concentrating, but they come with an amplified risk for developing dementia in the future. The glaring absence of treatments for such a widespread condition drove a team of scientists at Gladstone Institutes to uncover, on a molecular level, how traumatic brain injuries trigger neurodegeneration—and just as importantly, how to target that process to prevent long-term damage.
A new malaria vaccine appears to be "safe and highly immunogenic", with "promising efficacy", according to interim results of the phase 2b clinical trial conducted in African children. The vaccine candidate, named 'RH5.1/Matrix-M', is a blood-stage type, targeting the malaria-causing parasite when it is present in the blood -- the stage of the parasite's life cycle when symptoms begin to show in the affected person. The trial results were published in "The Lancet Infectious Diseases" journal. Malaria is caused by Plasmodium parasites, spread to humans through the bite of an infected female Anopheles mosquito. Symptoms usually appear in the 10-15 days following the bite, with mild symptoms being fever, chills and headache, while the severe ones can include fatigue, confusion, seizures, and difficulty in breathing.
A newer vaccine against hepatitis B virus was clearly superior to an older vaccine type in inducing a protective antibody response among people living with HIV who didn't respond to prior vaccination, according to the results of an international study led by a Weill Cornell Medicine investigator. The study, reported Dec. 1 in JAMA, showed that hepatitis B vaccine with a cytosine phosphoguanine adjuvant, known as HepB-CpG, (trade name Heplisav-B) induced protective levels of antibodies in up to 99.4 percent of the subjects who received it. Such protection was seen in only 80.6 percent of subjects who received hepatitis B vaccine with an aluminum hydroxide adjuvant, known as HepB-alum, (trade name Engerix-B).
The development of an effective vaccine against the hepatitis C virus (HCV) has posed a significant challenge for decades due to the high genetic diversity of the virus. A research team has now achieved promising results. Using epitope-focused immunogens, they were able to induce broadly neutralizing antibodies (bnAbs) in laboratory models for the first time.
Higher rates of certain cancers in countries, such as the UK, may be linked to two particular strains of bacteria. Targeting these with treatments or vaccines could help reduce the risk of colorectal, bladder, and prostate cancers. Researchers from the Wellcome Sanger Institute, the University of Helsinki, and collaborators investigated the differences in cancer incidence for colorectal, bladder and prostate cancers, and compared these to global data tracking Escherichia coli (E. coli) strains. Specifically, they looked at the two dominant E. coli strains that produce a substance that has been previously identified as a risk factor for colorectal cancer.
The All India Coordinating Committee of Royal College of Obstetricians & Gynecologists (AICC RCOG) has recommended mandatory vaccination of adolescents and young adults to prevent cervical cancer, a statement said on Monday. The RCOG panel supports HPV vaccination and advocates for its accessibility to all eligible individuals, as this represents a crucial step toward the prevention and control of HPV diseases in India, the statement said.
Researchers at Leiden University Medical Center and Radboud University Medical Center in the Netherlands have demonstrated promising safety and efficacy of a late-liver-stage attenuated malaria parasite vaccine in a small clinical trial. The study found that immunization with a genetically modified Plasmodium falciparum parasite, known as GA2, induced a favorable immune response and provided protective efficacy against malaria infection.
The World Health Organization (WHO) on Wednesday announced that it has granted Emergency Use Listing (EUL) for the LC16m8 mpox vaccine. According to the global health agency’s statement, this is the second mpox vaccine to be supported by WHO following the Director-General’s declaration of an mpox public health emergency of international concern (PHEIC) on 14 August 2024.
Ahead of World Lung Day, doctors emphasised that voluntary vaccination among adults can significantly reduce the incidence of lung infections, leading to fewer hospital admissions and less strain on the overburdened hospitals. In a press conference on Tuesday, doctors at Amrita Hospital, Faridabad revealed that the high morbidity and mortality rates associated with acute respiratory infections continue to pose a major challenge to the healthcare system. When a large portion of the population is vaccinated, it would also reduce the overall transmission of diseases by herd immunity, protecting even those who cannot be vaccinated such as infants or individuals with suppressed immune system, the doctors revealed.
The World Health Organisation on Friday said it has granted its first authorisation for use of a vaccine against mpox in adults, calling it an important step toward fighting the disease in Africa and beyond. The pre-qualification of the vaccine by Bavarian Nordic A/S means that donors like GAVI the Vaccine Alliance and UNICEF can buy it. But supplies are limited because there's only a single manufacturer.
IPF, the lung disease that claimed tabla maestro Zakir Hussain, is one of the most difficult conditions to treat because there is no proven medication. Specialists in Mumbai and Delhi said that two anti-fibrotic medications aimed at reducing the scarred lung tissues are the mainstay of IPF treatment.
Ten patients suffering from a mystery disease that has broken out in the Democratic Republic of the Congo have tested positive for malaria, the head of the World Health Organization (WHO) said. However, Dr Tedros Adhanom Ghebreyesus said the patients could have more than one disease simultaneously. “Of the 12 initial samples collected, 10 tested positive for malaria, although it’s possible that more than one disease is involved. Further samples will be collected and tested to determine the exact cause or causes,” a WHO spokesperson said on Tuesday.
Imlunestrant, an investigational next-generation selective estrogen receptor degrader (SERD), improved progression-free survival in patients with endocrine therapy-pretreated, ER-positive, HER2-negative advanced breast cancer—as monotherapy in patients with ESR1 mutations and as combination therapy with abemaciclib (Verzenio) in all patients, regardless of ESR1 mutation status—according to results from the phase III EMBER-3 clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10–13, 2024.
Scientists at the University of Helsinki, University of Eastern Finland and University of Turku are investigating the intricate ways in which various SARS-CoV-2 variants, like delta and omicron, interact with human cells to hijack their functions. This research is critical as it aims to uncover how these variants manipulate host cell processes, providing essential insights that could lead to the development of targeted antiviral therapies. Such knowledge is pivotal in the ongoing battle against COVID-19 and in preparing for future viral threats.
A group of scientists at VCU Massey Comprehensive Cancer Center has uncovered a new genetic code that deploys a cluster of cells that attack healthy organs and overpowers the normal cells. This discovery could introduce an entirely different understanding of the origins of cancer within the body, as well as offer insight into new treatments that could target the growth of tumors in their earliest stages.
Ninety percent of cancer deaths are due to the spread of cancer, not complications from the original tumor. Thus, for over 50 years now, scientists have been on a quest to identify which malignant mutations within the tumor allow rogue cells to break away from the primary tumor and travel through the bloodstream and lymphatic system to metastasize throughout the body.
Researchers at Karolinska Institutet and the University of Gothenburg have identified two types of metabolic-associated fatty liver disease – a liver-specific type and a systemic type that affects other organs and tissues. The discovery could lead to improved diagnosis and treatment of this growing patient group. Two studies are published back-to-back in Nature Medicine.
A new study demonstrates how universal genetic testing for breast cancer can ensure no patient is missed for advanced therapies. In a Canadian first, researchers led by William Foulkes, Distinguished James McGill Professor in McGill University’s Departments of Medicine, Oncology, and Human Genetics, tested over 700 women diagnosed with invasive breast cancer for genetic mutations associated with an increased risk for breast cancer, regardless of age or family history. The women were from diverse backgrounds.
A single modification in the protein found on the surface of the highly pathogenic avian influenza (HPAI) H5N1 influenza virus currently circulating in US dairy cows could allow for easier transmission among humans, according to new research funded by the National Institutes of Health (NIH) and published today in the journal Science. The study results reinforce the need for continued, vigilant surveillance and monitoring of HPAI H5N1 for potential genetic changes that could make the virus more transmissible in humans.
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